Ranolazine dihydrochloride

CAS No. 95635-56-6

Ranolazine dihydrochloride( RS-43285 )

Catalog No. M16826 CAS No. 95635-56-6

An anti-ischemic agent that has been shown to inhibit late I(Na) and I(Kr) and to have antiarrhythmic effects in various preclinical in vitro models.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
50MG 40 In Stock
100MG 56 In Stock
200MG 87 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Ranolazine dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    An anti-ischemic agent that has been shown to inhibit late I(Na) and I(Kr) and to have antiarrhythmic effects in various preclinical in vitro models.
  • Description
    An anti-ischemic agent that has been shown to inhibit late I(Na) and I(Kr) and to have antiarrhythmic effects in various preclinical in vitro models; also inhibits cardiac sodium channel Nav1.5, shows antiarrhythmic, antiepileptic, and analgesic effects.Other Indication Approved(In Vivo):Ranolazine (Bolus injection 10 mg/kg and infusion 9.6 mg/kg/h; bolus injection; for 145 minutes; male Wistar rats) treatment significantly reduces infarct size and cardiac troponin T release in rats subjected to left anterior descending coronary artery occlusion-reperfusion.
  • In Vitro
    ——
  • In Vivo
    Ranolazine (Bolus injection 10 mg/kg and infusion 9.6 mg/kg/h; bolus injection; for 145 minutes; male Wistar rats) treatment significantly reduces infarct size and cardiac troponin T release in rats subjected to left anterior descending coronary artery occlusion-reperfusion. Animal Model:Male Wistar rats (240-350 g) Dosage:Bolus injection 10 mg/kg and infusion (9.6 mg/kg/h) Administration:Bolus injection; for 145 minutes Result: Significantly reduced infarct size and cardiac troponin T release in rats subjected to left anterior descending coronary artery occlusion-reperfusion.
  • Synonyms
    RS-43285
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Sodium Channel
  • Recptor
    CalciumChannel|SodiumChannel
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    95635-56-6
  • Formula Weight
    500.4584
  • Molecular Formula
    C24H35Cl2N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    Cl.Cl.COC1=CC=CC=C1OCC(O)CN1CCN(CC(=O)NC2=C(C)C=CC=C2C)CC1
  • Chemical Name
    1-Piperazineacetamide, N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-, hydrochloride (1:2)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sokolov S, et al. Front Pharmacol. 2013 Jun 21;4:78. 2. Noble D, et al. Heart. 2006 Jul;92 Suppl 4:iv1-iv5. 3. Wang WQ, et al. J Pharmacol Exp Ther. 2008 Jun;325(3):875-81.
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